Neural Recordings from a Benzocyclobutene (BCB) Based Intra-cortical Neural Implant in an Acute Animal Model
نویسندگان
چکیده
Multi-channel micro-electrode arrays provide unmatched spatio-temporal resolution for assessing the activity of populations of neurons. These neural implants provide a powerful tool for developing a better understanding of cortical processing, as well as provide an intimate interface for neuroprosthetic applications. Over the years, micro-wire based devices that are manufactured by hand, have allowed researchers to record for several months, and in rare cases up to a year or more. Devices based on microelectro-mechanical systems (MEMs) offer more controlled designs with the added benefit of batch fabrication. Polymer-based MEMs interfaces offer exciting promise over traditional silicon arrays due to their mechanical flexibility and excellent biocompatibility. In this paper we microfabricated a neural interface using a new class of polymer known as Benzocyclobutene (BCB), developed for microelectronics under the trade name Cyclotene". This polymer has properties that we believe make it an attractive candidate for chronic implant applications. We provide for the first time a quantitative assessment of its recording capability in an acute animal model. Continuous recordings of neural signals (100 pV) from barrel cortex of a ra t were successfully demonstrated. These results a re encouraging for further development of a long term implant based on BCB. Keywords-Benzocyclobutene (BCB), polymer-based microelectrode array, neural interface, neuroprostheses
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تاریخ انتشار 2004